Obesity May Alter Immune System Response to COVID19
ISLAMABAD, Dec 31 (APP): In a new study on obesity scientists have found that obesity may cause a hyperactive immune system response to the Covid-19 infection which makes it difficult to fight the virus.
According to the study published in the journal ‘Endocrinology’, obesity not only leads to problems like heart disease and diabetes but also influences the immune system in many ways. Obesity causes chronic, low-grade activation of some parts of the immune system. When someone with this pre-existing condition is faced with an infection, it could lead to hyper-activation of the immune system but in a detrimental way that does not fight the infection, Medical Daily reported .
“The Covid-19 pandemic has made us aware of the complex interactions of obesity with infectious diseases and the gaps in our understanding of how chronic health conditions affect our immune responses to acute infection,” said study author Durga Singer from the University of Michigan in the US.
Recent evidence has highlighted how one part of the immune system, the macrophage, may be a culprit in driving severe Covid-19 disease.
“Our manuscript focuses on what is already known about the interaction of obesity, macrophages and other infections like influenza,” Singer added. “These findings highlight the importance of understanding how obesity might interact with new drugs or vaccines developed for Covid-19.”
In this review, the authors described the impact of obesity on the immune system. They discuss the irregular immune responses caused by obesity that drive organ injury in severe Covid-19 infection and impair a person’s ability to fight the virus.
“We consider that obesity-driven dysregulation of innate immune responses may drive organ injury in the development of severe Covid-19 and impair viral clearance,” the study authors wrote.
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