Scientists make a ‘Human-Mouse Chimera’
The human-mouse hybrid has the highest number of human cells ever recorded in an animal
Baaghi TV, 23rd May: Scientists have created an embryo containing both human and mouse cells in a major advancement in genetically modified organisms.
According to reports, the hybrid embryo created by the researchers is known as the Human-Mouse Chimera that is 4% human. It was grown by a team at the State University of New York at Buffalo and the Roswell Park Comprehensive Cancer Center.
The embryo contains 4% of human cells the highest proportion that has ever been achieved.
“It has not been possible to generate naïve human [stem cells] that substantially contribute to mouse embryos,” a paper detailing the research states.
“The generation of chimera-competent naïve [stem cells] unifies some common features of naïve [stem cells] in mammals and may enable applications such as human organ generation in animals.”
The experiment involved human blood cells and eye cells proving that it is possible to generate mature human cells at a quicker rate than is possible in a human embryo.
This could have significant implications for the treatment of human diseases, including the COVID-19 coronavirus, as it allows for cells, tissues, or organs to be grown for research purposes.
The human stem cells were injected into the mouse embryo and the scientists allowed them to develop for two weeks. On analyzing the embryo, scientists discovered human cells in the mouse’s brain, liver, eyes, blood, heart, and bone marrow.
However, the scientists did not gestate the embryo further, though there have been previous incidents where researchers have produced chimera hybrids beyond the fetus stage.
The research was published in the Journal of Science Advances.
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