US fast-tracking antimalarials to treat coronavirus

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Washington, March 19 (AFP/APP): The US is fast-tracking antimalarial drugs for use as a treatment against the new coronavirus, President Donald Trump said Thursday, following encouraging early results in France and China.

Chloroquine and hydroxychloroquine have not been given a formal green light in the US to fight the pandemic, but the Food and Drug Administration (FDA) said it would work with domestic makers to expand production as it studied their efficacy.

The drugs are already approved for malaria, lupus and rheumatoid arthritis, and doctors in the US may prescribe any drug they believe is appropriate medically.

“We’re going to be able to make that drug available almost immediately, and that’s where the FDA has been so great,” Trump told reporters, referring to both compounds.

The US has recorded 10,755 cases of new coronavirus infection, 154 of them fatal. But authorities expect the number to increase steeply in the coming days because of increased levels of testing after initial delays.

“If there is an experimental drug that is potentially available, a doctor could ask for that drug to be used in a patient. We have criteria for that and very speedy approval for that,” said FDA Commissioner Stephen Hahn.

“As an example, many Americans have read studies and heard media reports about this drug chloroquine, which is an anti-malarial drug.

“That’s a drug that the president directed us to take a closer look at, as to whether an expanded use approach to that could be done to actually see if that benefits patients.”

Chloroquine and hydroxychloroquine are synthetic forms of quinine, which is found in the barks of cinchona trees of Latin America and has been used to treat malaria for centuries.

Some in the wider scientific community have cautioned more research is needed to prove that they really work and are safe for COVID-19.

But French drugmaker Sanofi said on Wednesday it was ready to offer the French government millions of doses of hydroxychloroquine, sold under its brand name Plaquenil, in light of a “promising” study carried out by scientist Didier Raoult of the IHU Mediterranee Infection in Marseille.

Raoult reported this week that after treating 24 patients for six days with Plaquenil, the virus had disappeared in all but a quarter of them.

The research has not yet been peer-reviewed or published, and Raoult had come under fire by some scientists and officials in his native France for potentially raising false hopes.

“I’m just doing my duty, and I am happy to see that now eight or nine countries recommend chloroquine treatment for patients with this new coronavirus,” he told AFP.

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3 comments

  1. Dr K Chaudhry 20 March, 2020 at 16:58 Reply

    Malaria had been eradicated from India for a decade and staged a comeback during year 1971. Since 1971, several avtars of fever afflicted India. Viral fever, Dengue fever, Chikungunya – all began as killers. With time we learnt how to coexist with those diseases. Corona Virus showed up during recent months. That engulfed the entire World. The world would soon learn how to coexist with Corona Virus.
    Since year 1971, Chloroquine has been my default drug in fever cases. Viral fever, Dengue fever, Chikungunya – all political entities responded to Chloroquine. By simple mathemathics, there can be two possibilities :-
    1. New avtars of fever during consecutive years were new variants of malaria.
    2. Chloroquine known as antimalarial, may be nonspecific fever drug, effective also against Viral fever, Dengue fever, Chikungunya, and now Corona Virus.
    Chloroquine is a harmless drug with single dose required in endemic population and 5 tablet (double strength) course required elsewhere.
    Immunity boosters in routine and Chloroquine at first fever sign may be a magic mantra to make the World Corona free.
    Dr K Chaudhry http://immunity.indianmedical.net

  2. google 5 April, 2020 at 17:00 Reply

    I needed to thank you for this good read!!

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