COVID-19: Can mixing vaccines boost immune response?

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COVID-19: Can mixing vaccines boost immune response? #Baaghi

Most vaccines against COVID-19 are made in two doses, and almost everyone who gets both doses has the same vaccine, however, this trend is changing because some countries allow, and in some cases even encourage, two doses from two different vaccines.

According to details, the German government announced last Tuesday that 66-year-old Chancellor Angela Merkel had been injected with two different vaccines, which has boosted longer-lasting immunity against the pandemic virus and new variants of it, and offered more flexibility to vaccine rollout.

Some countries have performed this procedure as needed, when they have not been able to provide a specific vaccine, or as a precaution when it comes to vaccine safety for those who have received the first dose. However, the United States (US) has so far been reluctant to encourage such action.

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But health researchers and policymakers are interested in the fact that injecting different vaccines into one person could potentially have significant benefits.

What are the potential benefits of injecting two different vaccines?

Combining of vaccination, which scientists call “heterogeneous primary amplification,” is not a new idea, and researchers have tested it in some diseases, including Ebola.

Scientists have long theorized that injecting two slightly different vaccines into people may trigger a stronger immune response, perhaps because the vaccines stimulate different parts of the immune system or can detect different parts of the invasive virus.

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“How well this argument about COVID-19 disease works requires a real evaluation of the data,” said John Moore, a virologist at Cornell University’s Will Medical College in New York.

Zhou Xing, an immunologist at McMaster University in Canada, believes that in addition to the potential safety benefits of mixing and adapting, it also “provides the flexibility needed if vaccine supply sources are difficult or limited.”

Several clinical trials are currently underway to determine if the injection of the two different vaccines has advantages or disadvantages. Researchers at the University of Oxford in a study called Com-Cov are conducting various studies on combination of COVID-19 vaccines, including Astrazeneca-Oxford, Pfizer-Biontech, Moderna and Novavax, and US National Institutes of Health (NIH) has recently tested different combined doses.

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Russian researchers are also considering injecting Sputnik V with the Astrazeneca vaccine. Of course, the formula for the first dose of the Sputnik vaccine is different from the second dose.

Most studies are in the early stages, but the preliminary results of some studies and research have been promising. Last month, for example, a team of Spanish researchers reported that people who received a dose of the Astrazeneca vaccine followed by a dose of the Pfizer vaccine showed a stronger immune response.

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